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TSNAs

By Terry Martin, About.com

Updated: June 24, 2009

About.com Health's Disease and Condition content is reviewed by our Medical Review Board

Definition:

Tobacco-specific N-nitrosamines (TSNAs) are known to be some of the most potent carcinogens present in smokeless tobacco, snuff and tobacco smoke.

TSNAs consist of four chemical compounds:
  • N-nitrosonornicotine (NNN)
  • 4-methyl-N-nitrosamino-1-(3-pyridyl)-1-butanone (NNK)
  • N-nitrosoanatabine (NAT)
  • N-nitrosoanabasine (NAB)
Two of these chemical compounds, NNN and NNK, have been classifed as Group 2B carcinogens.

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